MGM-15.
MGM-15 is a synthetic mitragynine analog. It has been detected in adulterated supplements and in products falsely marketed under botanical names (e.g. 'Cat's Claw'). It is not a natural kratom alkaloid.
What it is
MGM-15 is a synthesized chemical analog of mitragynine — produced in the lab, not extracted from a plant. It shares the corynanthe-type indole alkaloid framework that defines kratom alkaloids but is not present in naturally-grown kratom.
Where it appears
Three contexts:
- Adulterated kratom or 7-OH products where the synthetic analog has been added without disclosure
- Supplements falsely marketed as "Cat's Claw" or other botanicals that have nothing to do with mitragynine
- Some "next-generation" products that explicitly label MGM-15 as an ingredient
The FDA and DEA have issued warnings and seizure actions involving MGM-15 [6, 7].
Pharmacology in brief
Published characterization is limited. Industry reporting suggests μ-opioid receptor activity with potency comparable to or exceeding 7-OH. Independent peer-reviewed pharmacology data is sparse as of mid-2026.
Safety concerns
- Undisclosed adulteration — the biggest risk is consuming MGM-15 in a product that doesn't list it on the label.
- Drug-test detection — MGM-15 does not always trigger standard opioid drug screens; users may inadvertently consume a μ-opioid agonist without it showing up on conventional testing.
- Polysubstance risk — combining MGM-15 with prescribed opioids, benzodiazepines, alcohol can cause additive respiratory depression.
Lab testing as defense
The most reliable defense against undisclosed-MGM-15 exposure is chain-of-custody analytical testing of the product. /LabTest walks through requesting an HPLC panel that includes synthetic-analog detection.
Legal status
The Federal Analogue Act may apply to MGM-15 sold for human consumption. Several states have updated kratom-alkaloid statutes to explicitly cover synthetic analogs. See /Legal.