Derivative & related compounds.
7-OH isn't the only molecule in this conversation. Some derivatives appear naturally in trace amounts in the kratom plant; others are entirely synthetic and have been showing up in adulterated supplements. What we know — and what's still unknown — for each.
Mitragynine Pseudoindoxyl
A naturally trace and synthetically accessible μ-opioid receptor agonist derived from mitragynine. Reported to be substantially more potent than 7-OH in animal studies.
Read02Dihydromitragynine
A hydrogenated derivative of mitragynine. Limited published characterization; sometimes appears in concentrated kratom extracts marketed as 'next-generation' products.
Read03MGM-15
Synthetic mitragynine analog reported in some seized samples and adulterated 'Cat's Claw'–branded products. Not a natural kratom alkaloid.
Read04MGM-16
Synthetic mitragynine analog, structurally related to MGM-15. Detected in adulterated supplements; minimal public pharmacology.
Read05SR-17018
Experimental synthetic μ-opioid receptor agonist (Bohn lab, Scripps). Not a kratom alkaloid but adjacent — some users report using it during kratom-stop attempts.
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